That discovery was made by researchers from Wageningen Bioveterinary Research, part of Wageningen University & Research in the Netherlands. The outcome was published recently in the peer-reviewed journal Emerging Microbes & Infections, a publication of Nature.
The research, of course, was done as pigs share many anatomical and physiological features with humans.
Zika virus, Zika fever, and microcephaly
Although discovered in 1947, Zika virus became notorious in 2015-16 as it caused a Zika fever epidemic in predominantly Latin America.
The mosquito-borne flavivirus became associated with microcephaly in newborns – a condition where the head is smaller than normal. The virus is also associated
Study design: 20 piglets inoculated
The scientists inoculated 20 porcine fetuses in utero and assessed the effect of Zika virus on brain development 4 weeks later. All inoculated fetuses presented mild to severe neuropathology, characterized by a depletion of neurons in the cerebral cortex. In most cases, neuronal depletion was confined to specific cerebral lobes without affecting brain size, whereas in severe cases a more generalized depletion resulted in microcephaly.
Although the virus was widespread in the sows’ placenta at the time of necropsy, only low levels of viral RNA were detected in fetal brain samples, thereby preventing the identification of primary target cells.
In their publication, the researchers said that their findings suggest that pigs can be used to study Zika virus-induced neuro-developmental defects as currently observed in human neonates, varying from stunted brain growth to localized cortical neuronal depletion in the absence of major macroscopic abnormalities.
Zika virus models – why pigs are ideal
First insights into Zika virus-mediated neuropathology came from studies with mice, the university reported on its website. However, the major differences in the physiology, anatomy, and development of the rodent and human brain makes extrapolation of observations made in mouse experiments to humans not always appropriate. Using non-human primates, from a research viewpoint a good
Implications of the use of pigs
The presented fetal pig model can be used to study fundamental aspects of congenital Zika virus syndrome and may facilitate the evaluation of Zika virus therapeutics. The study also supports the notion that congenital Zika virus infection induces more than just microcephaly.
Source: Pigprogress.net